A protein-protein interaction map reveals that the Coxiella burnetii effector CirB inhibits host proteasome activity.
Coxiella burnetii is the etiological agent of the zoonotic disease Q fever, which is featured by its ability to replicate in acid vacuoles resembling the lysosomal network.One key virulence determinant of C.burnetii is the Dot/Icm system that transfers more than 150 effector proteins into host cells.These effectors function to construct the lysosom