A PROTEIN-PROTEIN INTERACTION MAP REVEALS THAT THE COXIELLA BURNETII EFFECTOR CIRB INHIBITS HOST PROTEASOME ACTIVITY.

A protein-protein interaction map reveals that the Coxiella burnetii effector CirB inhibits host proteasome activity.

Coxiella burnetii is the etiological agent of the zoonotic disease Q fever, which is featured by its ability to replicate in acid vacuoles resembling the lysosomal network.One key virulence determinant of C.burnetii is the Dot/Icm system that transfers more than 150 effector proteins into host cells.These effectors function to construct the lysosom

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A new approach in philosophy of education

Philosophy is the method of correct thinking, the way of wise living, and the effort for understanding the existence.We face a diverse range of philosophies such as philosophy of religion, philosophy of art, philosophy of science, philosophy of various sciences, and philosophy of education.It is this philosophy of education which is the subject of

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The spatial distribution of GRBs

We analysed the different aspects of the spatial distribution of 542 Gamma-Ray Bursts with precisely determined positions and spectroscopic redshifts.The data were divided according to the origin of the redshift (afterglow or host galaxy).The yearly nightstick twm-850xl rate of afterglow and host-based redshift observations are different, with only

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A cell-based assay for detection of anti-fibrillarin autoantibodies with performance equivalent to immunoprecipitation

Anti-fibrillarin autoantibodies are useful for the diagnosis and prognosis of systemic sclerosis (SSc).Anti-fibrillarin produces a clumpy nucleolar pattern in trip in the woods sierra nevada indirect immunofluorescence assay on HEp-2 cells (HEp-2 IFA).Here we develop and validate a reliable cell-based anti-fibrillarin assay (Fibrillarin/CBA) for us

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